CD36/SR-A double knock-outs
Availability: in stock, currently can be shipped
To inquire about obtaining these mice contact Mason Freeman.
The SR-A null mice were originally generated by Suzuki et al (A role for
macrophage scavenger receptors in atherosclerosis and susceptibility to
infection, Nature; 1997:386:292-296). They were generously provided to the
Freeman lab by Dr. T. Kodama. They have been back-bred in C57BL6/J mice
for at least 6 generations. They have been intercrossed with CD36 null mice
generated by the Freeman lab and described under the CD36 deficient link.
These mice are housed at Charles River Laboratories and will be shipped
directly from CRL.
Kunjathoor, V. V., Febbraio, M., Podrez, E. A., Moore, K. J.,
Andersson, L., Koehn, S., Rhee, J. S., Silverstein, R., Hoff, H. F.,
and Freeman, M. W. Scavenger receptors class A-I/II and CD36 are the
principal receptors responsible for the uptake of modified low
density lipoprotein leading to lipid loading in macrophages (2002). J
Biol Chem 277, 49982-49988
Shipping and handling charges are subject to CRL costs and are borne by
the requesting lab.
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