CD36/SR-A double knock-outsAvailability: in stock, currently can be shipped To inquire about obtaining these mice contact Mason Freeman. The SR-A null mice were originally generated by Suzuki et al (A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection, Nature; 1997:386:292-296). They were generously provided to the Freeman lab by Dr. T. Kodama. They have been back-bred in C57BL6/J mice for at least 6 generations. They have been intercrossed with CD36 null mice generated by the Freeman lab and described under the CD36 deficient link. These mice are housed at Charles River Laboratories and will be shipped directly from CRL. Kunjathoor, V. V., Febbraio, M., Podrez, E. A., Moore, K. J., Andersson, L., Koehn, S., Rhee, J. S., Silverstein, R., Hoff, H. F., and Freeman, M. W. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages (2002). J Biol Chem 277, 49982-49988 Shipping and handling charges are subject to CRL costs and are borne by the requesting lab. |
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