ParaBioSys - Parallel Biological Systems - MGH, HMS, BU
Projects
Signal Transduction
Host-Pathogen Interactions
Protein Networks/RNA Display
Macrophage Activation
Resources
Software Tools
Microarrays
Bacterial Pathogens
Animal Models
Education
Classes
Seminars
Workshops
About Us
PGA Project Summary
Research Centers
Faculty & Staff
Publications
Policies and Procedures
Terms and Conditions
Data Sharing and Usage
Animal Distribution
Quality Control
Citing Us
Search
Search the Entire PGA
 

Genetic Dissection of Stress Pathway Signal Transduction

Principal Investigator: Brian Seed

Overview

Recent evidence has suggested that cytokine and stress signaling pathways may be intimately involved in the pathophysiology of cardiovascular diseases. The nearly ubiquitous expression of cytokine receptors and the increasing evidence that many cell types outside the immune system are affected by inflammatory signals argue for a closer examination of the underlying signal transduction pathways.

Specific Aims:

  1. To create reporter cell lines that allow identification of genes promoting activation of stress and inflammation pathways.
  2. To develop and exploit automated sib selection strategies to identify new molecules that activate stress and inflammation pathways.
  3. To use microarray analysis to understand the genotypes of mutant cell lines bearing lesions in stress and inflammation signal transduction pathways.

Learn More

To learn more about the Genetic Dissection of Stress Pathway Signal Transduction project, Visit the Seed Lab Web Site.

NHLBI Home Page | NHLBI-PGA Home Page | Webmaster