Genetic Dissection of Stress Pathway Signal Transduction
Principal Investigator: Brian Seed
Recent evidence has suggested that cytokine and stress
signaling pathways may be intimately involved in the pathophysiology of
cardiovascular diseases. The nearly ubiquitous expression of cytokine
receptors and the increasing evidence that many cell types outside the
immune system are affected by inflammatory signals argue for a closer
examination of the underlying signal transduction pathways.
- To create reporter cell lines that allow identification
of genes promoting activation of stress and inflammation pathways.
- To develop and exploit automated sib selection strategies to identify
new molecules that activate stress and inflammation pathways.
- To use microarray analysis to understand the genotypes
of mutant cell lines bearing lesions in stress and inflammation signal
To learn more about the Genetic Dissection of Stress Pathway Signal Transduction project, Visit the Seed Lab Web Site.